Ekinomitsin - Echinomycin

Ekinomitsin
Ismlar
	Boshqa ismlar Kinomitsin A; Levomitsin
Identifikatorlar
CAS raqami	512-64-1 ;
3D model (JSmol )	Interaktiv rasm;
ChemSpider	5257063 ;
ECHA ma'lumot kartasi	100.164.832
PubChem CID	6857732;
UNII	TG824J6RQT ;
CompTox boshqaruv paneli (EPA)	DTXSID5031266 ;
	InChI InChI = 1S / C51H64N12O12S2 / c1-25 (2) 38-49 (72) 74-22-36 (59-42 (65) 34-21-53-30-17-13-15-19-32 (30) 57-34) 44 (67) 55-28 (6) 46 (69) 63 (10) 40-48 (71) 62 (9) 39 (26 (3) 4) 50 (73) 75-23-35 ( 58-41 (64) 33-20-52-29-16-12-14-18-31 (29) 56-33) 43 (66) 54-27 (5) 45 (68) 60 (7) 37 ( 47 (70) 61 (38) 8) 24-77-51 (40) 76-11 / h12-21,25-28,35-40,51H, 22-24H2,1-11H3, (H, 54,66) ) (H, 55,67) (H, 58,64) (H, 59,65) / t27-, 28-, 35 +, 36 +, 37-, 38-, 39-, 40 +, 51? / m0 / s1 Kalit: AUJXLBOHYWTPFV-VITLIGDRSA-N ; InChI = 1 / C51H64N12O12S2 / c1-25 (2) 38-49 (72) 74-22-36 (59-42 (65) 34-21-53-30-17-13-15-19-32 (30) 57-34) 44 (67) 55-28 (6) 46 (69) 63 (10) 40-48 (71) 62 (9) 39 (26 (3) 4) 50 (73) 75-23-35 ( 58-41 (64) 33-20-52-29-16-12-14-18-31 (29) 56-33) 43 (66) 54-27 (5) 45 (68) 60 (7) 37 ( 47 (70) 61 (38) 8) 24-77-51 (40) 76-11 / h12-21,25-28,35-40,51H, 22-24H2,1-11H3, (H, 54,66) ) (H, 55,67) (H, 58,64) (H, 59,65) / t27-, 28-, 35 +, 36 +, 37-, 38-, 39-, 40 +, 51? / m0 / s1 Kalit: AUJXLBOHYWTPFV-VITLIGDRBO;
	Jilmayganlar C [C @ H] 1C (= O) N ([C @ H] 2CSC ([C @@ H] (C (= O) N ([C @ H] (C (= O) OC [C @ H ”) ] (C (= O) N1) NC (= O) c3cnc4ccccc4n3) C (C) C) C) N (C (= O) [C @@ H] (NC (= O) [C @@ H]) COC (= O) [C @@ H] (N (C2 = O) C) C (C) C) NC (= O) c5cnc6ccccc6n5) C) C) SC) C;
Xususiyatlari
Kimyoviy formulalar	C51H64N12O12S2
Molyar massa	1101,26 g / mol
	Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar berilgan standart holat (25 ° C [77 ° F], 100 kPa da).
	tasdiqlang (nima bu ?)
	Infobox ma'lumotnomalari

Ekinomitsin a peptid antibiotik. Bu interkalatlar ichiga DNK ikkita aniq saytda, shu bilan bog'lanishni to'sib qo'yadi gipoksiya induktsiya qiluvchi omil 1 alfa (HIF1alfa).

Biosintez

Ekinomitsin - bis-interkalator peptid va noyob tomonidan biosintez qilinadi nonribosomal peptid sintetaza (NRPS).^[1]^[2] Ekinomitsin kabi turli bakteriyalardan ajratib olinadi Streptomitsiyalar lazalienis. Bu kinoksalin oilasiga tegishli antibiotiklar. Ushbu birikma guruhiga katta qiziqish mavjud, chunki ular juda kuchli antibakterial, saratonga qarshi va virusga qarshi ta'sirga ega.^[3]

Echinomitsinning biosintezi QC molekulasidan boshlanadi. L-triptofan QC uchun kashshof va uning biosintezi birinchi bosqichga parallel nikkomitsin biosintez. QC biosintez qilinganidan so'ng adenillanish domen o'z ichiga olgan Ecm1 yog 'kislotasi biosintezi yordamida QC ni faollashtiradi va FabC ga o'tkazadi asil tashuvchisi oqsili (ACP). Birinchi modul Ecm6 boshlang'ich birligi sifatida QC-SFabC ni qabul qiladi. Emc7 da terminal mavjud tioesteraza peptidning xiralashishiga va keyin chiqarilishiga imkon beruvchi domen. Ushbu siklizlangan mahsulot keyinchalik oksidreduktaza hosil qiluvchi Ecm17 ga o'tadi disulfid bog'lanish Ushbu biosintezning so'nggi bosqichi disulfid bog'lanishini a ga aylantiradi tioatsetal ko'prik. Ushbu o'zgarish Ecm18 bilan sodir bo'ladi, bu unga juda o'xshash S-adenosil-L-metionin (SAM) - bog'liqdir metiltransferaza.^[3]

Adabiyotlar

^ Vatanabe, K; Oguri, H; Oikava, H (aprel, 2009). "Xinomenzimatik sintez va echinomitsin biosintez yo'lining heterologik ekspresiyasi orqali echinomitsin molekulyar tuzilishini diversifikatsiyasi". Kimyoviy biologiyaning hozirgi fikri. 13 (2): 189–96. doi:10.1016 / j.cbpa.2009.02.012. PMID 19278894.
^ Sato M, Nakazava T, Tsunematsu Y, Hotta K, Vatanabe K (2013). "Ekinomitsin biosintezi". Kimyoviy biologiyaning hozirgi fikri. 17 (4): 537–45. doi:10.1016 / j.cbpa.2013.06.022. PMID 23856054.
^ ^a ^b Vatanabe, K; va boshq. (2006 yil avgust). "Escherichia coli tarkibidagi antitumor nonribosomal peptidlarning umumiy biosintezi". Tabiat kimyoviy biologiyasi. 2 (8): 423–8. doi:10.1038 / nchembio803. PMID 16799553. S2CID 40607322.

Ushbu tizimli antibiotik bilan bog'liq maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[Watanabe-1] Vatanabe, K; Oguri, H; Oikava, H (aprel, 2009). "Xinomenzimatik sintez va echinomitsin biosintez yo'lining heterologik ekspresiyasi orqali echinomitsin molekulyar tuzilishini diversifikatsiyasi". Kimyoviy biologiyaning hozirgi fikri. 13 (2): 189–96. doi:10.1016 / j.cbpa.2009.02.012. PMID 19278894.

[pmid23856054-2] Sato M, Nakazava T, Tsunematsu Y, Hotta K, Vatanabe K (2013). "Ekinomitsin biosintezi". Kimyoviy biologiyaning hozirgi fikri. 17 (4): 537–45. doi:10.1016 / j.cbpa.2013.06.022. PMID 23856054.

[Watanabe2-3] Vatanabe, K; va boshq. (2006 yil avgust). "Escherichia coli tarkibidagi antitumor nonribosomal peptidlarning umumiy biosintezi". Tabiat kimyoviy biologiyasi. 2 (8): 423–8. doi:10.1038 / nchembio803. PMID 16799553. S2CID 40607322.

[1]

[2]

[3]

Ismlar

Boshqa ismlar Kinomitsin A; Levomitsin
Identifikatorlar
CAS raqami	512-64-1^Y
3D model (JSmol )	Interaktiv rasm
ChemSpider	5257063^N
ECHA ma'lumot kartasi	100.164.832
PubChem CID	6857732
UNII	TG824J6RQT^Y
CompTox boshqaruv paneli (EPA)	DTXSID5031266
InChI InChI = 1S / C51H64N12O12S2 / c1-25 (2) 38-49 (72) 74-22-36 (59-42 (65) 34-21-53-30-17-13-15-19-32 (30) 57-34) 44 (67) 55-28 (6) 46 (69) 63 (10) 40-48 (71) 62 (9) 39 (26 (3) 4) 50 (73) 75-23-35 ( 58-41 (64) 33-20-52-29-16-12-14-18-31 (29) 56-33) 43 (66) 54-27 (5) 45 (68) 60 (7) 37 ( 47 (70) 61 (38) 8) 24-77-51 (40) 76-11 / h12-21,25-28,35-40,51H, 22-24H2,1-11H3, (H, 54,66) ) (H, 55,67) (H, 58,64) (H, 59,65) / t27-, 28-, 35 +, 36 +, 37-, 38-, 39-, 40 +, 51? / m0 / s1^N Kalit: AUJXLBOHYWTPFV-VITLIGDRSA-N^N InChI = 1 / C51H64N12O12S2 / c1-25 (2) 38-49 (72) 74-22-36 (59-42 (65) 34-21-53-30-17-13-15-19-32 (30) 57-34) 44 (67) 55-28 (6) 46 (69) 63 (10) 40-48 (71) 62 (9) 39 (26 (3) 4) 50 (73) 75-23-35 ( 58-41 (64) 33-20-52-29-16-12-14-18-31 (29) 56-33) 43 (66) 54-27 (5) 45 (68) 60 (7) 37 ( 47 (70) 61 (38) 8) 24-77-51 (40) 76-11 / h12-21,25-28,35-40,51H, 22-24H2,1-11H3, (H, 54,66) ) (H, 55,67) (H, 58,64) (H, 59,65) / t27-, 28-, 35 +, 36 +, 37-, 38-, 39-, 40 +, 51? / m0 / s1 Kalit: AUJXLBOHYWTPFV-VITLIGDRBO
Jilmayganlar C [C @ H] 1C (= O) N ([C @ H] 2CSC ([C @@ H] (C (= O) N ([C @ H] (C (= O) OC [C @ H ”) ] (C (= O) N1) NC (= O) c3cnc4ccccc4n3) C (C) C) C) N (C (= O) [C @@ H] (NC (= O) [C @@ H]) COC (= O) [C @@ H] (N (C2 = O) C) C (C) C) NC (= O) c5cnc6ccccc6n5) C) C) SC) C
Xususiyatlari
Kimyoviy formulalar	C₅₁H₆₄N₁₂O₁₂S₂
Molyar massa	1101,26 g / mol
Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar berilgan standart holat (25 ° C [77 ° F], 100 kPa da).
N tasdiqlang (nima bu ^YN ?)
Infobox ma'lumotnomalari