Glutation S-transferaza teta-2 bu ferment odamlarda kodlanganligi GSTT2 gen .[5] [6] [7]
Glutation S-transferaza (GSTs) teta 2 (GSTT2) - bu kamaytirilgan glutationning konjugatsiyasini turli xil elektrofil va gidrofobik birikmalarga katalizator qiluvchi superfilamiya a'zosi. Inson GSTlarini beshta asosiy sinfga bo'lish mumkin: Alfa, Mu, Pi, Teta va Zeta. Theta sinfining a'zolari GSTT1 va GSTT2 55% aminokislotalar ketma-ketligi identifikatoriga ega va ularning ikkalasi ham inson kanserogenezida muhim rol o'ynaydi. Teta genlari bir xil ekzon / intron chegaralariga ega bo'lgan beshta ekzonsdan iborat bo'lib, shunga o'xshash tuzilishga ega.[7]
Adabiyotlar
^ a b v ENSG00000277897 GRCh38: Ensembl chiqishi 89: ENSG00000099984, ENSG00000277897 - Ansambl , 2017 yil may^ a b v GRCm38: Ensembl relizi 89: ENSMUSG00000033318 - Ansambl , 2017 yil may^ "Human PubMed ma'lumotnomasi:" . Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi .^ "Sichqoncha PubMed ma'lumotnomasi:" . Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi .^ Tan KL, Uebb GC, Baker RT, Board PG (Iyul 1995). "CDNA ning molekulyar klonlashi va odamning teta sinfidagi glutation S-transferaza genini (GSTT2) 22-xromosomaga xromosomal lokalizatsiyasi". Genomika . 25 (2): 381–7. doi :10.1016 / 0888-7543 (95) 80037-M . PMID 7789971 . ^ Coggan M, Whitbread L, Whittington A, Board P (noyabr 1998). "Insonning teta sinfidagi glutation S-transferaza va D-dopaxrom tautomeraza gen kompleksining tuzilishi va tashkil etilishi" . Biokimyo J . 334 (3): 617–23. doi :10.1042 / bj3340617 . PMC 1219731 . PMID 9729470 . ^ a b "Entrez Gen: GSTT2 glutation S-transferase theta 2" .Qo'shimcha o'qish
Xussey AJ, Xeyz JD (1992). "Inson sinfining xarakteristikasi - Theta glutation S-transferaza, 1-menaftil sulfatga nisbatan faolligi" . Biokimyo. J . 286 (3): 929–35. doi :10.1042 / bj2860929 . PMC 1132992 . PMID 1417752 . Whittington AT, Webb GC, Baker RT, Board PG (1996). "Sichqoncha teta sinfidagi glutation transferonaz mGSTT2 sinfini kodlovchi cDNA va genning xarakteristikasi va uning 10B5-C1 xromosomasiga joylashishi". Genomika . 33 (1): 105–11. doi :10.1006 / geno.1996.0165 . PMID 8617493 . Vebb G, Vaska V, Koggan M, Kengash P (1996). "Insonning teta sinfi glutation transferaz (GSTT1) uchun genning xromosomal lokalizatsiyasi". Genomika . 33 (1): 121–3. doi :10.1006 / geno.1996.0167 . PMID 8617495 . Mainwaring GW, Uilyams SM, Foster JR va boshq. (1996). "Sichqoncha, kalamush va odamning jigar va o'pkasida teta-klassli glutation S-transferazlarning tarqalishi" . Biokimyo. J . 318 (1): 297–303. doi :10.1042 / bj3180297 . PMC 1217621 . PMID 8761485 . Bonaldo MF, Lennon G, Soares MB (1997). "Normallashtirish va ayirish: genlarni kashf etishni osonlashtirish uchun ikkita yondashuv" . Genom Res . 6 (9): 791–806. doi :10.1101 / gr.6.9.791 . PMID 8889548 . Chelvanayagam G, Wilce MC, Parker MW va boshq. (1997). "GSTT2 Theta sinfining glutation transferazasi uchun odam uchun gomologik model". Oqsillar . 27 (1): 118–30. doi :10.1002 / (SICI) 1097-0134 (199701) 27: 1 <118 :: AID-PROT12> 3.0.CO; 2-Q . PMID 9037717 . Rossjohn J, McKinstry WJ, Oakley AJ va boshq. (1998). "Inson teta sinfidagi glutation transferaz: kristalli struktura ko'milgan faol maydonda sulfat bilan bog'lovchi cho'ntakni ochib beradi". Tuzilishi . 6 (3): 309–22. doi :10.1016 / S0969-2126 (98) 00034-3 . PMID 9551553 . de Bruin WC, Wagenmans MJ, Board PG, Peters WH (1999). "Glyutation S-transferaza teta sinfidagi izofermentlarning inson kolorektal va oshqozon saratonida ifodalanishi" . Kanserogenez . 20 (8): 1453–7. doi :10.1093 / kanser / 20.8.1453 . PMID 10426791 . Dunham I, Shimizu N, Roe BA va boshqalar. (1999). "Inson xromosomasining DNK ketma-ketligi 22" . Tabiat . 402 (6761): 489–95. doi :10.1038/990031 . PMID 10591208 . de Bruin WC, Wagenmans MJ, Peters WH (2000). "Glutation S-transferaz alfa, P1-1 va T1-1 odamning oshqozon-ichak traktida ekspressioni" . Jpn. J. Saraton kasalligi . 91 (3): 310–6. doi :10.1111 / j.1349-7006.2000.tb00946.x . PMC 5926361 . PMID 10760690 . Sprenger R, Schlagenhaufer R, Curb R va boshq. (2001). "Glutation S-transferaza GSTT1 o'chirilishining xarakteristikasi: barcha genotiplarni polimeraza zanjiri reaktsiyasi bilan diskriminatsiya qilish trimodular genotip-fenotip korrelyatsiyasini ko'rsatadi". Farmakogenetika . 10 (6): 557–65. doi :10.1097/00008571-200008000-00009 . PMID 10975610 . Venter JC, Adams MD, Myers EW va boshq. (2001). "Inson genomining ketma-ketligi" . Ilm-fan . 291 (5507): 1304–51. doi :10.1126 / science.1058040 . PMID 11181995 . Strausberg RL, Feingold EA, Grouse LH va boshq. (2003). "15000 dan ortiq to'liq uzunlikdagi odam va sichqonchani cDNA sekanslarini yaratish va dastlabki tahlil qilish" . Proc. Natl. Akad. Ilmiy ish. AQSH . 99 (26): 16899–903. doi :10.1073 / pnas.242603899 . PMC 139241 . PMID 12477932 . De Maria F, Pedersen JZ, Caccuri AM va boshq. (2004). "Tabiiy NO tashuvchisi bo'lgan dinitrosil-diglutationil-temir kompleksining glutation transferazning superfamilasi bilan o'ziga xos o'zaro ta'siri: azot oksidini saqlash yo'nalishi bo'yicha evolyutsion bosim to'g'risida taklif" . J. Biol. Kimyoviy . 278 (43): 42283–93. doi :10.1074 / jbc.M305568200 . PMID 12871945 . Kollinz JE, Rayt CL, Edvards KA va boshq. (2005). "Odamning ORFeome-ni klonlash uchun genom annotatsiyasiga asoslangan yondashuv" . Genom Biol . 5 (10): R84. doi :10.1186 / gb-2004-5-10-r84 . PMC 545604 . PMID 15461802 . Gerxard DS, Vagner L, Feingold EA va boshq. (2004). "NIH to'liq metrajli cDNA loyihasining holati, sifati va kengayishi: sutemizuvchilar genlari to'plami (MGC)" . Genom Res . 14 (10B): 2121-7. doi :10.1101 / gr.2596504 . PMC 528928 . PMID 15489334 . Jang SG, Kim IJ, Kang XS va boshqalar. (2007). "GSTT2 promouter polimorfizmlari va kolorektal saraton xavfi" . BMC saratoni . 7 : 16. doi :10.1186/1471-2407-7-16 . PMC 1793996 . PMID 17250773 . PDB galereyasi
1ljr : INSONDAN GLUTATHIONE TRANSFERASE (HGST T2-2)
2ljr : GLUTATHIONE TRANSFERASE INO IN APO-FORM
3ljr : 1-MENAFTHIL SULFATINING GLUTATHION KONYUGATASI BILAN KOMPLEKSKA INSONDAN GLUTATHIONE TRANSFERASE (Theta Class).