KIF17 - KIF17

KIF17
Identifikatorlar
TaxalluslarKIF17, Kif17, 5930435E01Rik, AW492270, Kif17b, mKIAA1405, KIF3X, KLP-2, OSM-3, kinesin oila a'zosi 17
Tashqi identifikatorlarOMIM: 605037 MGI: 1098229 HomoloGene: 5883 Generkartalar: KIF17
Gen joylashuvi (odam)
Xromosoma 1 (odam)
Chr.Xromosoma 1 (odam)[1]
Xromosoma 1 (odam)
KIF17 uchun genomik joylashuv
KIF17 uchun genomik joylashuv
Band1p36.12Boshlang20,664,014 bp[1]
Oxiri20,718,017 bp[1]
RNK ekspressioni naqsh
PBB GE KIF17 222144 da fs.png
Qo'shimcha ma'lumotni ifodalash ma'lumotlari
Ortologlar
TurlarInsonSichqoncha
Entrez
Ansambl
UniProt
RefSeq (mRNA)

NM_001122819
NM_001287212
NM_020816

NM_001190978
NM_010623

RefSeq (oqsil)

NP_001116291
NP_001274141
NP_065867

NP_001177907
NP_034753

Joylashuv (UCSC)Chr 1: 20.66 - 20.72 MbChr 4: 138.25 - 138.3 Mb
PubMed qidirmoq[3][4]
Vikidata
Insonni ko'rish / tahrirlashSichqonchani ko'rish / tahrirlash

Kinesinga o'xshash protein KIF17 a oqsil odamlarda kodlanganligi KIF17 gen.[5][6] KIF17 va uning yaqin qarindoshi, C. elegans OSM-3,[7] ning a'zolari kinesin -2 plyus-end oilasiga yo'naltirilgan mikrotubula asoslangan vosita oqsillari.[8] Heterotrimerik kinesin-2 dvigatellaridan farqli o'laroq,[9] ammo, KIF17 va OSM-3 ajralib turadi homodimerik komplekslar.[10] Homodimerik kinesin-2 transportida ishtirok etgan NMDA retseptorlari birga dendritlar dendritik membranaga etkazib berish uchun,[5] ikkalasi ham heterotrimerik va homodimerik kinesin-2 dvigatellari anterogradda hamkorlikda ishlaydi intraflagellar tashish (IFT) va siliyum biogenez.[11][12]

Adabiyotlar

  1. ^ a b v GRCh38: Ensembl relizi 89: ENSG00000117245 - Ansambl, 2017 yil may
  2. ^ a b v GRCm38: Ensembl relizi 89: ENSMUSG00000028758 - Ansambl, 2017 yil may
  3. ^ "Human PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.
  4. ^ "Sichqoncha PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.
  5. ^ a b Setou M, Nakagava T, Seog DH, Xirokava N (iyun 2000). "NMDA retseptorlari o'z ichiga olgan pufak transportida Kinesin superfamily vosita oqsil KIF17 va mLin-10". Ilm-fan. 288 (5472): 1796–802. doi:10.1126 / science.288.5472.1796. PMID  10846156.
  6. ^ "Entrez Gen: KIF17 kinesin oila a'zosi 17".
  7. ^ Shakir MA, Fukushige T, Yasuda H, Miwa J, Siddiqui SS (iyul 1993). "C. elegans osm-3 geni ozmotik qochish xatti-harakatlarida vositachilik qiladi, kinesinga o'xshash oqsilni kodlaydi". NeuroReport. 4 (7): 891–4. doi:10.1097/00001756-199307000-00013. PMID  7690265.
  8. ^ Lawrence CJ, Dawe RK, Christie KR, Klivlend DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM , Schliwa M, Scholey JM, Vale RD, Walczak Idoralar, Wordeman L (2004 yil oktyabr). "Standartlashtirilgan kinesin nomenklaturasi". J. Hujayra Biol. 167 (1): 19–22. doi:10.1083 / jcb.200408113. PMC  2041940. PMID  15479732.
  9. ^ Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM (1993 yil noyabr). "Dengiz kirpi tuxumidan tozalangan yangi heterotrimerik kinesin bilan bog'liq oqsil". Tabiat. 366 (6452): 268–70. doi:10.1038 / 366268a0. PMID  8232586.
  10. ^ Signor D, Wedaman KP, Rose LS, Scholey JM (1999 yil fevral). "Xemosensor neyronlardagi ikkita heteromerik kinesin kompleksi va Caenorhabditis elegans sezgir kirpiklari". Mol. Biol. Hujayra. 10 (2): 345–60. doi:10.1091 / mbc.10.2.345. PMC  25173. PMID  9950681.
  11. ^ Snow JJ, Ou G, Gunnarson AL, Walker MR, Zhou HM, Brust-Mascher I, Scholey JM (2004 yil noyabr). "Ikki anterograd intraflagellar transport dvigatellari C. elegans neyronlarida sezgir kipriklarni yaratish uchun hamkorlik qiladi". Nat. Hujayra biol. 6 (11): 1109–13. doi:10.1038 / ncb1186. PMID  15489852.
  12. ^ Dishinger JF, Kee HL, Jenkins PM, Fan S, Hurd TW, Hammond JW, Truong YN, Margolis B, Martens JR, Verhey KJ (iyul 2010). "Kinesin-2 dvigatelining siliyerga kirishi KIF17 importin-beta2 va RanGTP bilan tartibga solinadi". Nat. Hujayra biol. 12 (7): 703–10. doi:10.1038 / ncb2073. PMC  2896429. PMID  20526328.

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