Tironamin

Tironamin
Ismlar


IUPAC nomi 4- [4- (2-Aminoetil) fenoksi] fenol
Identifikatorlar
CAS raqami	500-78-7^N
3D model (JSmol )	Interaktiv rasm
ChEMBL	ChEMBL201896^Y
ChemSpider	2340781^Y
MeSH	tironamin
PubChem CID	3083601
CompTox boshqaruv paneli (EPA)	DTXSID60198174
InChI InChI = 1S / C14H15NO2 / c15-10-9-11-1-5-13 (6-2-11) 17-14-7-3-12 (16) 4-8-14 / h1-8,16H, 9-10,15H2^Y Kalit: OVUVNKDANCKDCK-UHFFFAOYSA-N^Y InChI = 1 / C14H15NO2 / c15-10-9-11-1-5-13 (6-2-11) 17-14-7-3-12 (16) 4-8-14 / h1-8,16H, 9-10,15H2 Kalit: OVUVNKDANCKDCK-UHFFFAOYAP
Jilmayganlar O (c1ccc (cc1) CCN) c2ccc (O) cc2
Xususiyatlari
Kimyoviy formulalar	C₁₄H₁₅NO₂
Molyar massa	229.279 g · mol⁻¹
Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
N tasdiqlang (nima bu ^YN ?)
Infobox ma'lumotnomalari

Tironamin ham molekulaga, ham shu molekulaning hosilalariga taalluqlidir: dekarboksillangan va degiodizatsiyalangan metabolitlar ning qalqonsimon bez gormonlari tiroksin (T4) va 3,5,3'-triiodotironin (T3).

Turlari

Guruhga quyidagilar kiradi:

Tironamin (T0AM)
3-yodotironamin (T1AM), bu eng mashhuri, chunki u a iz omin topilgan asab tizimi. Bu tabiiy ligand uchun mumkin bo'lgan nomzod iz omin bilan bog'liq retseptorlari TAAR1 (TAR1), hujayra ichidagi G oqsillari bilan bog'langan retseptorlari^[1]
3,5-diiodotironamin (T2AM)
3,5,3'-Triiodotironamin (T3AM)

Shuningdek qarang

Adabiyotlar

^ Piehl S, Hoefig CS, Scanlan TS, Köhrle J (2011). "Tironaminlar - o'tmish, hozirgi va kelajak". Endokrin sharhlar. 32 (1): 64–80. doi:10.1210 / er.2009-0040. PMID 20880963.

Qalqonsimon bez gormoni metabolik vositalar
Tirozin / yodotirozin	3-yodotirozin Diodotirozin
Tironin / yodotironin	3'-monoidodironin 3,3'-diiodotironin 3,5-diiodotironin 3,3 ', 5-triiodotironin (T₃) 3,3 ', 5'-Triiodotironin (teskari T₃) 3,5,3 ', 5'-Tetraiodotironin (Tiroksin, T₄)
Tironamin / yodotironamin	3-yodotironamin 3,3 ', 5-Triiodotironamin
Iodotiratsetat / yodotiratsetik kislota	Triiodotiratsetat (TRIAC)

Inson izi omin bilan bog'liq retseptorlari ligandlar

TAAR1

Agonistlar

Endogen^†	Klassik monoamin nörotransmitterlari Dopamin Gistamin Norepinefrin Serotonin Aminlarni kuzatib boring 3-yodotironamin 3-metoksitiramin N-Metilfenetilamin N-Metiltiramin m-Oktopamin p-Oktopamin Fenetilamin Feniletanolamin Sinefrin Triptamin m-Tiramin p-Tiramin
Sintetik^‡	Amfetamin DOB DOET 4-gidroksiamfetamin Izoprenalin MDA (tenamfetamin) MDMA (midomafetamin) 2-metilfenetilamin 3-metilfenetilamin 4-metilfenetilamin b-metilfenetilamin Metamfetamin 3-MMA Norfenfluramin Phentermine o-PIT Propilheksedrin RO5166017 N,N-Dimetilfenetilamin

Neytral antagonistlar

Teskari agonistlar

EPPTB (RO5212773)

TAAR2

Agonistlar^‡
Neytral antagonistlar

TAAR5

Agonistlar^‡	N,N-Dimetiletilamin Trimetilamin
Neytral antagonistlar
Teskari agonistlar^‡	3-yodotironamin

^† Insonning barcha endogen TAAR1 ligandlari uchun ma'lumotnomalar Amin izlari ro'yxati

^‡ Sintetik TAAR1 agonistlari uchun ma'lumotnomani bu erda topishingiz mumkin TAAR1 yoki tegishli qo'shma maqolalarda. TAAR2 va TAAR5 agonistlari va teskari agonistlari uchun qarang TAAR ma'lumotnomalar uchun.

Shuningdek qarang: Retseptor / signalizatsiya modulyatorlari

Fenetilaminlar
Fenetilaminlar	Psixelika: 25B-NBOMe 25C-NBOMe 25D-NBOMe 25I-NBOMe 25N-NBOMe 2C-B 2C-B-AN 2C-Bn 2C-Bu 2C-C 2C-CN 2C-CP 2C-D 2C-E 2C-EF 2C-F 2C-G 2C-G-1 2C-G-2 2C-G-3 2C-G-4 2C-G-5 2C-G-6 2C-G-N 2C-H 2C-I 2C-iP 2C-N 2C-NH2 2C-O 2C-O-4 2C-P 2C-Ph 2C-SE 2C-T 2C-T-2 2C-T-3 2C-T-4 2C-T-5 2C-T-6 2C-T-7 2C-T-8 2C-T-9 2C-T-10 2C-T-11 2C-T-12 2C-T-13 2C-T-14 2C-T-15 2C-T-16 2C-T-17 2C-T-18 2C-T-19 2C-T-20 2C-T-21 2C-T-22 2C-T-22.5 2C-T-23 2C-T-24 2C-T-25 2C-T-27 2C-T-28 2C-T-30 2C-T-31 2C-T-32 2C-T-33 2C-TFE 2C-TFM 2C-YN 2C-V Allyselkalin DESOKSI Eskalin Izoproskalin Jimkalin Makromerin MEPEA Meskalin Meteskalin Metalleskalin Proskalin Psi-2C-T-4 TCB-2 Venlafaksin Stimulyatorlar: Feniletanolamin Hordenine Fenetilamin a-metilfenetilamin (amfetamin) b-metilfenetilamin m-Metilfenetilamin N-Metilfenetilamin o-Metilfenetilamin p-Metilfenetilamin Metilfenidat Entaktogenlar: Lopofin MDPEA MDMPEA Boshqalar: BOH DMPEA
Amfetaminlar	Psixelika: 3C-BZ 3C-E 3C-P Alef Beatris Bromo-DragonFLY D-Deprenil DMA DMCPA DMMDA DOB DOC DOEF DOET DOI DOM DON DOPR DOTFM Ganesha MMDA MMDA-2 Psi-DOM TMA TeMA Stimulyatorlar: 2-FA 2-FMA 3-FA 3-FMA Acridorex Alfetamin Amfekloral Amfepentorex Amfetamin (Dekstroamfetamin, Levoamfetamin ) Amfetaminil Benfloreks Benzfetamin Ketin Klobenzoreks Dimetilamfetamin Efedrin Etilamfetamin Fencamfamin Fenkamin Fenetillin Fenfluramin (Dexfenfluramin, Levofenfluramin ) Fenproporeks Flucetorex Fludoreks Formetorex Furfenoreks Gefefrin 4-gidroksiamfetamin Iofetamin Izopropilamfetamin Lefetamin Lisdexamfetamin Mefenorex Metaraminol Metamfetamin (Dekstrometamfetamin, Levometamfetamin ) Metoksifenamin MMA Morforex Norfenfluramin L -Norsevdoefedrin N, alfa-dietilfeniletilamin Oxifentorex Oksilofrin Ortetamin PBA PCA Fenprometamin PFA PFMA PIA PMA PMEA PMMA Fenilpropanolamin Fledrin Prenilamin Propilamfetamin Psödoefedrin Sibutramin Tifloreks Tranilsipromin Ksilopropamin Zilofuramin Entaktogenlar: 4-FA 4-FMA 4-MA 4-MMA 4-MTA 5-APB 5-APDB 5-EAPB 5-IT 5-MAPB 5-MAPDB 6-APB 6-APDB 6-Xloro-MDMA 6-EAPB 6-IT 6-MAPB 6-MAPDB EDA IAP 2,3-MDA 3,4-MDA (tenamfetamin) MDEA MDHMA MDMA (midomafetamin) MDOH Metamnetamin MMDMA Naftilaminopropan TAP Boshqalar: 3,4-DCA Amiflamin DiFMDA Selegilin (shuningdek D. -Deprenil )
Fenterminalar	Stimulyatorlar: Xlorfentermin Cloforex Klortermin Etolorex Mefentermin Pentorex Phentermine Entaktogenlar: MDPH MDMPH Boshqalar: Seriklamin
Katinonlar	Stimulyatorlar: 3-FMC 4-MC 4-BMC 4-CMC 4-EMC 4-FMC 4-MEC 4-MeMABP 4-MPD Amfepramon Benzedron Brephedron Bufedron Bupropion Katinon Dimetilkatinon Etkatinon Evtilon Gidroksibupropion Metkatinon Methedron NEB N-etilheksedron N-etilpentrone Pentrone Pentilon Radafaksin Entaktogenlar: 3,4-DMMC 3-MMC Butilon Etilon Metilon Metilenedioksikatinon Mefedron
Fenilizobutilaminlar	Entaktogenlar: 4-CAB 4-MAB Ariadne BDB Butilon EBDB Evtilon MBDB Stimulyatorlar: Fenilizobutilamin
Fenilalkilpirrolidinlar	Stimulyatorlar: a-PBP a-PHP a-PPP a-PVP MDPBP MDPPP MDPV 4-MePBP 4-MePHP 4-MePPP MOPPP MOPVP MPBP MPHP MPPP Nafiron PEP Prolintan Pirovaleron
Katekolaminlar (va yaqin qarindoshlari)	6-FNE 6-OHDA a-Me-DA a-Me-TRA Adrenoxrom Siladopa D. -DOPA (Dekstrodopa) Dimetofrin Dopamin Epinefrin Epinin Etilefrin Etilnorepinefrin Fenklonin Ibopamin Izoprenalin Isoetarin L -DOPA (Levodopa) L -DOPS (Droksidopa) L -Fenilalanin L -Tirozin m-Tiramin Metanefrin Metaraminol Metaterol Metirozin Metildopa N, N-dimetildopamin Nordefrin (Levonordefrin ) Norepinefrin Norfenefrin (m-Oktopamin) Normetanephrine Orsiprenalin p-Oktopamin p-Tiramin Fenilefrin Sinefrin
Turli xil	AL-LAD Amidefrin Arbutamin Kafedrin Denopamin Desvenlafaksin Difenidin Dizosilpin Dobutamin Dopeksamin Efenidin Etafedrin ETH-LAD Famprofazon Ftorolintan Geksapradol IP-LAD Lizerjik kislota amidi Liserjik kislota 2-butil amid Lizerjik kislota 2,4-dimetilazetidid Lizerjik kislota dietilamid Metoksamin Metoksfenidin MT-45 PARGY-LAD Phenibut PRO-LAD Pronetalol Salbutamol (Levosalbutamol ) Solriamfetol Teodrenalin Tiamfenikol UWA-101

Tironamin - Thyronamine

Turlari

Shuningdek qarang

Adabiyotlar