Retinil asetat - Retinyl acetate

Retinil asetat
Ismlar
	IUPAC nomi (2E,4E,6E,8E) -3,7-Dimetil-9- (2,6,6-trimetilsikloheks-1-en-1-yl) nona-2,4,6,8-tetraen-1-il asetat
	Boshqa ismlar Retinol asetat; A vitamini asetat; A vitamini1 asetat; Asetilretinol; hamma-trans-Retinol asetat; hamma-trans-Etrinatsetat; hamma-trans- A vitamini asetat;
Identifikatorlar
CAS raqami	127-47-9 ;
3D model (JSmol )	Interaktiv rasm;
ChemSpider	553599;
ECHA ma'lumot kartasi	100.004.405
PubChem CID	638034;
UNII	3LE3D9D6OY ;
CompTox boshqaruv paneli (EPA)	DTXSID6021240 ;
	InChI InChI = 1S / C22H32O2 / c1-17 (9-7-10-18 (2) 14-16-24-20 (4) 23) 12-13-21-19 (3) 11-8-15-22 ( 21,5) 6 / h7,9-10,12-14H, 8,11,15-16H2,1-6H3 / b10-7 +, 13-12 +, 17-9 +, 18-14 + Kalit: QGNJRVVDBSJHIZ-QHLGVNSISA-N; InChI = 1 / C22H32O2 / c1-17 (9-7-10-18 (2) 14-16-24-20 (4) 23) 12-13-21-19 (3) 11-8-15-22 ( 21,5) 6 / h7,9-10,12-14H, 8,11,15-16H2,1-6H3 / b10-7 +, 13-12 +, 17-9 +, 18-14 + Kalit: QGNJRVVDBSJHIZ-QHLGVNSIBE;
	Jilmayganlar O = C (OC / C = C (/ C = C / C = C (/ C = C / C1 = C (/ CCCC1 (C) C) C) C) C) C);
Xususiyatlari
Kimyoviy formulalar	C22H32O2
Molyar massa	328.496 g · mol−1
Erish nuqtasi	57 dan 58 ° C gacha (135 dan 136 ° F gacha; 330 dan 331 K gacha)
Xavf
R-iboralar (eskirgan)	R38 -R63
S-iboralar (eskirgan)	S36 / 37
NFPA 704 (olov olmos)	1 1 0
	Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
	Infobox ma'lumotnomalari

Retinil asetat (retinol asetat, A vitamini asetat) tabiiydir^{[shubhali – muhokama qilish]} shakli A vitamini qaysi atsetat Ester ning retinol. U potentsial antineoplastik va ximopreventiv tadbirlar.^[2]^[3]

Qo'shma Shtatlarda retinil asetat tasniflanadi odatda xavfsiz deb tan olingan (GRAS) oziq-ovqat mahsulotlarini A vitamini bilan boyitish uchun ishlatiladigan miqdorda.^[4]^[5]

Toksikologiya

Jahon sog'liqni saqlash tashkilotining homiladorlik paytida onalarga qo'shimcha ovqatlanish bo'yicha tavsiyasida "homiladorlik paytida istalgan vaqtda 10000 IU A vitaminidan (3000mcg RE) oshmaydigan sutkalik qo'shimchadan ona va uning rivojlanayotgan homilasi uchun sog'liq uchun foydasi kutiladi, bu ham ozroq zarar etkazishi mumkin. . " Oldindan tuzilgan A vitamini retinil palmitat va retinil asetatni nazarda tutadi. ^[6]

Adabiyotlar

^ ^a ^b ^v Retinil asetat dan Sigma-Aldrich
^ Oy, Richard S.; Grubbs, Klinton J.; Sporn, Maykl B.; Goodman, Dawn G. (1977). "Retinilatsetat N-metil-N-nitrosourea tomonidan kelib chiqqan sut karsinogenezini inhibe qiladi". Tabiat. 267 (5612): 620–1. doi:10.1038 / 267620a0. PMID 876383. S2CID 4211886.
^ Retinil asetat, Milliy saraton instituti Giyohvand moddalar lug'ati
^ GRAS moddalari bo'yicha qo'mitani tanlang (SCOGS) Fikr: A vitamini, Amerika Qo'shma Shtatlari oziq-ovqat va farmatsevtika idorasi
^ 21 C.F.R. 184.1930
^ http://whqlibdoc.who.int/hq/1998/WHO_NUT_98.4_eng.pdf

[SA-1] v Retinil asetat dan Sigma-Aldrich

[2] Oy, Richard S.; Grubbs, Klinton J.; Sporn, Maykl B.; Goodman, Dawn G. (1977). "Retinilatsetat N-metil-N-nitrosourea tomonidan kelib chiqqan sut karsinogenezini inhibe qiladi". Tabiat. 267 (5612): 620–1. doi:10.1038 / 267620a0. PMID 876383. S2CID 4211886.

[3] Retinil asetat, Milliy saraton instituti Giyohvand moddalar lug'ati

[4] GRAS moddalari bo'yicha qo'mitani tanlang (SCOGS) Fikr: A vitamini, Amerika Qo'shma Shtatlari oziq-ovqat va farmatsevtika idorasi

[5] 21 C.F.R. 184.1930

[6] ttp://whqlibdoc.who.int/hq/1998/WHO_NUT_98.4_eng.pdf

[1]

[2]

[3]

[4]

[5]

[6]

Ismlar

IUPAC nomi (2E,4E,6E,8E) -3,7-Dimetil-9- (2,6,6-trimetilsikloheks-1-en-1-yl) nona-2,4,6,8-tetraen-1-il asetat
Boshqa ismlar Retinol asetat; A vitamini asetat; A vitamini₁ asetat; Asetilretinol; hamma-trans-Retinol asetat; hamma-trans-Etrinatsetat; hamma-trans- A vitamini asetat;
Identifikatorlar
CAS raqami	127-47-9^Y
3D model (JSmol )	Interaktiv rasm
ChemSpider	553599
ECHA ma'lumot kartasi	100.004.405
PubChem CID	638034
UNII	3LE3D9D6OY^Y
CompTox boshqaruv paneli (EPA)	DTXSID6021240
InChI InChI = 1S / C22H32O2 / c1-17 (9-7-10-18 (2) 14-16-24-20 (4) 23) 12-13-21-19 (3) 11-8-15-22 ( 21,5) 6 / h7,9-10,12-14H, 8,11,15-16H2,1-6H3 / b10-7 +, 13-12 +, 17-9 +, 18-14 + Kalit: QGNJRVVDBSJHIZ-QHLGVNSISA-N InChI = 1 / C22H32O2 / c1-17 (9-7-10-18 (2) 14-16-24-20 (4) 23) 12-13-21-19 (3) 11-8-15-22 ( 21,5) 6 / h7,9-10,12-14H, 8,11,15-16H2,1-6H3 / b10-7 +, 13-12 +, 17-9 +, 18-14 + Kalit: QGNJRVVDBSJHIZ-QHLGVNSIBE
Jilmayganlar O = C (OC / C = C (/ C = C / C = C (/ C = C / C1 = C (/ CCCC1 (C) C) C) C) C) C)
Xususiyatlari
Kimyoviy formulalar	C₂₂H₃₂O₂
Molyar massa	328.496 g · mol⁻¹
Erish nuqtasi	57 dan 58 ° C gacha (135 dan 136 ° F gacha; 330 dan 331 K gacha)^[1]
Xavf
R-iboralar (eskirgan)	R38 -R63^[1]
S-iboralar (eskirgan)	S36 / 37^[1]
NFPA 704 (olov olmos)	1 1 0
Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
Infobox ma'lumotnomalari